Inequities of power in gender and sexuality are powerful factors influencing health and development. ICRW and CARE jointly designed and implemented the innovative Inner Spaces, Outer Faces Initiative (ISOFI) to find more effective ways of addressing these inequities in CARE’s reproductive health programs, starting with a pilot phase in India and Vietnam. This toolkit results from the program’s first phase and is a compilation of training, reflection and monitoring activities. These activities helped to identify, explore, and challenge the social constructions of gender and sexuality in the lives of project staff, the lives of project beneficiaries, program interventions, and CARE as an institution. The toolkit can be used by staff of development and health organizations to increase the understanding of gender and sexuality issues by both staff and community members, and how these issues relate to reproductive health.